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July 2023


ICSH, the International Council for Standardization in Haematology is pleased to announce the Publication of a new ICSH Guideline for laboratory measurement of factor VIII and factor IX type I inhibitors.


Author Contributions


Piet Meijer: Drafting manuscript.


Flora Peyvandi, Guy Young, Rajiv Pruthi, Simara de Lima Montalvao and Steve Kitchen critically reviewed, edited and approved the final manuscript.


Abstract


Prepared on behalf of the International Council for Standardisation in Haematology, the aim of the document is to provide guidance and recommendations on the measurement of factor VIII (FVIII) and factorIX (FIX) inhibitors.


After an introduction on the clinical background and relevance of factor VIII and factor IX inhibitor testing, the following aspects of laboratory testing are included: screening for inhibitors, assay principle, sample requirements, testing requirements and interpretation, quality assurance, interferences and recent developments.


This guidance document focusses on recommendations for a standardised procedure for the laboratory measurement of FVIII and FIX type I inhibitors.


The recommendations are based on published data in peer-reviewed literature and expert opinion.


Published


First published: 07 June 2023


By the International Journal of Laboratory Hematology Volume 45, Issue 4 Aug 2023 Pages i-iv, 405-619


The publication is available to:


 

ABOUT ICSH


The International Council for Standardization in Haematology (ICSH) was initiated as a standardization committee by the European Society of Haematology (ESH) in 1963 and officially constituted by the International Society of Hematology (ISH) and the ESH in Stockholm in 1964.


​The ICSH is a not-for-profit non-governmental organisation that aims to achieve reliable and reproducible results in laboratory analysis in the field of diagnostic haematology.


​The ICSH coordinates Working Groups of experts to examine laboratory methods and instruments for haematological analyses, to deliberate on issues of standardization and to stimulate and coordinate scientific work as necessary towards the development of international standardization materials and guidelines.



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May 2023


  • Research Technician Carly Olafson awarded the ICSH Carol Briggs-Smalley Scholarship

  • Highest number of award entries for 5 years


The International Council for Standardization in Haematology (ICSH) is pleased to announce Carly Olafson of Canadian Blood Services in Canada has been awarded the ICSH Carol Briggs-Smalley Scholarship.


The title of Carly's Project is "Standardization of Hemolysis Measurement in Red Cell Concentrates" and the ICSH is looking forward to Carly starting her project.


Promoted with the help of its corporate partners, affiliates and Wiley Publishing, and with an increase to £10,000 in value, this year saw the ICSH Carol Briggs-Smalley Award highest number of entires in 5 years.


The Carol Briggs-Smalley Scholarship Award was set-up in 2015 to honour the significant contributions Carol Briggs made to the discipline of laboratory haematology.


Each year the ICSH seeks applications from Medical Technologists and Medical Laboratory Scientists on laboratory haematology projects particularly those that are related to standardization in laboratory haematology.


Projects related to standardization in cellular analysis, haemostasis, flow cytometry, haemoglobinopathies and molecular haematology are all considered to be suitable for the award.


The amount of £10,000 GBP is allocated to the successful applicant for expenses related to the project.


The ICSH Carol Briggs-Smalley Award is one of two annual ICSH scholarship awards, this and the ICSH Sam Machin Award.


 

ABOUT ICSH


The International Council for Standardization in Haematology (ICSH) was initiated as a standardization committee by the European Society of Haematology (ESH) in 1963 and officially constituted by the International Society of Hematology (ISH) and the ESH in Stockholm in 1964.


​The ICSH is a not-for-profit non-governmental organisation that aims to achieve reliable and reproducible results in laboratory analysis in the field of diagnostic haematology.

The ICSH coordinates Working Groups of experts to examine laboratory methods and instruments for haematological analyses, to deliberate on issues of standardization and to stimulate and coordinate scientific work as necessary towards the development of international standardization materials and guidelines.


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07 March 2023


ICSH, the International Council for Standardization in Haematology is pleased to announce the Publication of a new ICSH Guideline.


Written by David A. Fitzmaurice, Geert-Jan Geersing, Xavier Armoiry, Sam Machin, Steve Kitchen, and Ian Mackie.


This guideline has been written on behalf of the International Council for Standardisation in Haematology (ICSH) and focuses on two point of care (POC) haematology tests used within primary care, namely International Normalised Ratio (INR) and D-dimer. Primary care covers out of hospital settings and can include General Practice (GP), Pharmacy and other non-hospital settings.


This guidance is intended for use by health care professionals performing INR or D-dimer tests in those locations (although these guidelines would also be applicable to hospital out-patient settings).


Links to the full publication can be found at the ICSH Publications page - here



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